GPCR Aptamer Catalog

Conformationally Correct Aptamers to Over 400 GPCR Targets

BasePair will be releasing these products in tranches of aptamers to ~50 GPCRs every few weeks. If you don’t see your favorite target of interest, please contact us and get your target prioritized in our queue.

Why BasePair GPCR Aptamers?

• Conformationally correct (membrane-presented target)
• Suitable for functional assays, screening, and more
• Non-natural DNA aptamers — stable & customizable
• Available now for over 400 GPCR targets — catalog below

GPCR Target	Alias	Primary Indication
CYSLTR1	CysLT1	Asthma (HPA)
GIPR	—	Type 2 diabetes (HPA)
OPRK1	KOR	Chronic pain (HPA)
GNRHR	GnRHR	Prostate cancer (HPA)
OPRM1	MOR	Chronic pain (HPA)
P2RY12	—	Thrombosis (HPA)
CHRM5	M5	Alzheimer’s disease (HPA)
HTR1B	5-HT1B	Migraine (HPA)
HTR1D	5-HT1D	Migraine (HPA)
GHRHR	—	Growth hormone deficiency (HPA)
GLP2R	—	Short bowel syndrome (HPA)
ADORA1	A1R	Parkinson’s disease (HPA)
AVPR2	V2R	Diabetes insipidus (HPA)
ADORA2A	A2AR	Parkinson’s disease (HPA)
BDKRB2	B2R	Hereditary angioedema (HPA)
SSTR4	—	Neuroendocrine tumors (HPA)
HTR1F	5-HT1F	Migraine (HPA)
HTR2C	5-HT2C	Obesity (HPA)
HTR4	5-HT4	Irritable bowel syndrome (HPA)
MTNR1A	Mel1a	Insomnia (HPA)
ADRA2A	Alpha-2A	Hypertension (HPA)
CCR4	CC-CKR-4	T-cell lymphoma (TCGA)
CNR1	CB1	Epilepsy (HPA)
CCR10	CC-CKR-10	Psoriasis (HPA)
GPR75	—	Obesity (HPA)
GPR37L1	—	multiple or TBD
CMKLR1	Chemerin receptor	Psoriasis (HPA)
GPR78	—	multiple or TBD
CCR2	CC-CKR-2	Rheumatoid arthritis (HPA)
GPR4	—	multiple or TBD
GPR82	—	multiple or TBD
CCR6	CC-CKR-6	Psoriasis (HPA)
CNR2	CB2	Chronic pain (HPA)
GPR42	—	multiple or TBD
GPR39	—	Obesity (HPA)
GPR83	—	multiple or TBD
F2RL2	PAR3	multiple or TBD
CXCR5	CXC-R5	Rheumatoid arthritis (HPA)
GPRC5B	—	multiple or TBD
F2RL3	PAR4	Thrombosis (HPA)
CXCR6	CXC-R6	Hepatitis (HPA)
GRM4	mGluR4	Parkinson’s disease (HPA)
FFAR1	GPR40	Type 2 diabetes (HPA)
FFAR2	GPR43	Inflammatory bowel disease (HPA)
GPRC5D	—	Multiple myeloma (HPA)
HTR1E	5-HT1E	multiple or TBD
MC3R	—	Obesity (HPA)
ACKR3	CXCR7	Breast cancer (HPA)
LPAR2	LPA2	Ovarian cancer (HPA)
MC5R	—	Obesity (HPA)
GHSR	—	Obesity (HPA)
ACKR4	CCRL1	multiple or TBD
LPAR4	LPA4	Cancer (HPA)
GPR12	—	multiple or TBD
MCHR1	MCH1R	Obesity (HPA)
ADCYAP1R1	PAC1	Migraine (HPA)
LPAR5	LPA5	Cancer (HPA)
LPAR3	LPA3	Cancer (HPA)
MRGPRD	—	Chronic pain (HPA)
GPR182	ADGRG1	Cancer (HPA)
GPR156	—	multiple or TBD
GPR151	—	multiple or TBD
OPN4	Melanopsin	Circadian rhythm disorders (HPA)
NPBWR2	GPR8	multiple or TBD
GPR183	EBI2	Multiple sclerosis (HPA)
OPN5	—	Circadian rhythm disorders (HPA)
GPR152	—	multiple or TBD
NPFFR2	NPFF2	Chronic pain (HPA)
GPR19	—	Cancer (HPA)
ADORA2B	A2BR	Inflammation (HPA)
GPR160	—	Cancer (HPA)
GPR21	—	Obesity (HPA)
BRS3	—	Obesity (HPA)
NPFFR1	NPFF1	Chronic pain (HPA)
CRHR1	CRF1	Anxiety disorders (HPA)
CCR9	CC-CKR-9	Inflammatory bowel disease (HPA)
CCR7	CC-CKR-7	Lymphoma (HPA)
GPR84	—	Inflammation (HPA)
GPR45	—	multiple or TBD
CRHR2	CRF2	Anxiety disorders (HPA)
GPR87	—	Cancer (HPA)
CCR8	CC-CKR-8	Cancer (HPA)
ACKR1	DARC	Inflammation (HPA)
GPR55	—	Chronic pain (HPA)
CX3CR1	CX3C-R1	Atherosclerosis (HPA)
CCRL2	—	Inflammation (HPA)
GPR61	—	multiple or TBD
FPR1	—	Inflammation (HPA)
FPR2	—	Inflammation (HPA)
HCAR1	GPR81	Metabolic disorders (HPA)
FPR3	—	Inflammation (HPA)
DRD5	D5R	multiple or TBD
HCAR3	GPR109B	Metabolic disorders (HPA)
GRPR	—	Prostate cancer (HPA)
GPR137	—	Cancer (HPA)
MRGPRE	—	Chronic pain (HPA)
ADGRB3	BAI3	multiple or TBD
LPAR6	LPA6	Cancer (HPA)
GPR139	—	multiple or TBD
MRGPRF	—	Chronic pain (HPA)

Don’t see your GPCR of interest?
➜ We offer custom aptamer discovery to additional GPCRs — contact us to discuss.
➜ Full catalog (>400 GPCRs) available on request.

< script >
function sortTable(n) {
var table, rows, switching, i, x, y, shouldSwitch, dir, switchcount = 0;
table = document.getElementById(“gpcrTable”);
switching = true;
dir = “asc”;
while (switching) {
switching = false;
rows = table.rows;
for (i = 1; i < (rows.length - 1); i++) { shouldSwitch = false; x = rows[i].getElementsByTagName("TD")[n]; y = rows[i + 1].getElementsByTagName("TD")[n]; if (dir == "asc") { if (x.innerHTML.toLowerCase() > y.innerHTML.toLowerCase()) {
shouldSwitch = true;
break;
}
} else if (dir == “desc”) {
if (x.innerHTML.toLowerCase() < y.innerHTML.toLowerCase()) { shouldSwitch = true; break; } } } if (shouldSwitch) { rows[i].parentNode.insertBefore(rows[i + 1], rows[i]); switching = true; switchcount++; } else { if (switchcount == 0 && dir == "asc") { dir = "desc"; switching = true; } } } } function searchTable() { var input, filter, table, tr, td, i, j, txtValue; input = document.getElementById("searchInput"); filter = input.value.toLowerCase(); table = document.getElementById("gpcrTable"); tr = table.getElementsByTagName("tr"); for (i = 1; i < tr.length; i++) { tr[i].style.display = "none"; td = tr[i].getElementsByTagName("td"); for (j = 0; j < td.length; j++) { if (td[j]) { txtValue = td[j].textContent || td[j].innerText; if (txtValue.toLowerCase().indexOf(filter) > -1) {
tr[i].style.display = “”;
break;
}
}
}
}
}

function changeEntries() {
var select = document.getElementById(“entriesSelect”);
var limit = parseInt(select.value);
var table = document.getElementById(“gpcrTable”);
var tr = table.getElementsByTagName(“tr”);
for (var i = 1; i < tr.length; i++) { if (i <= limit) { tr[i].style.display = ""; } else { tr[i].style.display = "none"; } } } window.onload = function() { changeEntries(); };